i -· ' 3 · by c ithority of 137475 1 ·-- d ite Ju c 1977 · · · --- - - - - _- --------------- - E2 I DZ ' i CL BY 187475 · ' - - - - · ' · ·' - ' · · ·r · - - 7 - i S · - ·· - - · _ 7 June 1930 - · _ - t- - · -_ --- • - _ - ·- - - 11£ viO Ll NDUJ 'I FOR ' 'I E R E COR D - -- -• __f _- · J --- - · t - - _ _ ' r' c ' -- - - -- _ _- - _ · ' _· - - SU-BJEeT- · - -•- ··- c -r- ' KULTHA ·-Subproject 47· - - • - •• •• •_ _ ·- • - • • - - _ J 4 - - • ·- ·· · '·' - • _ - - - t tt if ' 'f - -- - - ·- · · ·· _· - -- - -- - - - - _ J • •· -- - -- -- - _ • i · - --' ' •- - - ---- -- - -- - j at- · ' -· _ · - · - _·1 t ' h -p f th i pr iect is_ to P M #y ' - -- '- · - · _ continue the research progra m car ducted b y fhis pros ram is desi gned to ex loit all the knowledge and facilit ie_s available to its director in pro · · · i-· viding answers to specific questions of direct interest to the · - _ _ · Age_n cy _ fu addition those areas of basic knowledge' required - · __ - _·· to provide these practiC a Lins ver s _will be developed It · ·- · '· ·· ··should be noted that a lthough the att ached pr oposal 6scribes the facilities which ·will be used in t he s tu j the rogram its elf was deliberately desc -ibed in F Ener il ov rt t e r ms in orde - to comply with its uncl' 3-s sified statu s - - · ·· v• • - -· _- 2 ·· i - - -- - -'·- · _ · i -- 1 i - - · · ' ·- · ·· · • · - # • _ • a · A relatively small part of the pro gr am - · wHl be in the fundamenta l field of the · elatior s hip of st_ructure to activity ·· -This basic s tudy ' vill be of a n overt · · nature and will se rve he purpose of _- maintaining cover for the • support cf the program ' ' -· - j ' - - • · • •r-• - I • - 'f - · -- _ ·- ·' · - ' -- --· - - - ·•· ·- - - - · - _ - - _-_ - •i f the above it is desir ed to describe n ore · -·_· · · · spec ifically the var i ol s· phases of the gener al prog rc r 1 here __ · - _' ·- - - - _-- _ - ·- · - -1 ·- -·· lJo - i clcd· to •·· _ ''- ' 'l½v w• • J• · ·-·' • • f' ' l ' • · - · t tt 1 2 D PD T CL BY 1 8 475 ••• ·• · _· - -- ••-• •• - - • - -- -- -- -- ·· ·•· _ - ·- ·_- - - _ - •••• - 4 - - ••I•- • · J- -·· • •- · ••• -- ·- · · - · _· ·- · ' ' - ·-- - - -- _i _ - - - - · _ t •- - - · - - _ _ · _ ' - TSS · · --- C-hern ica -l---D i vis irnrby -another '' iif§ 0Jti' A enc _co onent · · -· _ • - - •• _ _ · - _ -- • _ _ ----- _ •• 1 - -' ·- -· ·_ _- -- _ · -- · _ ' ' · t _ · c _ A _third phase of the _program will pr o v ide screening and evalaation 'a · •' f ' - • - - _· _- · -·· of compounds submitted by TSS CD •- · - - · - - -• in c luding the phases involvin g tests · · ·· · _ i n human volunteers · - L J j iaiSt i mri f 1 t r · -· · -- - - _ - i- - · _ __ _ lb A se ond phase will 'be represe nt e by · -' -'· · ·· a-n exten_s_i c- effort on behalf of - - - · - -- · • · · ·- ·· 0 t · -· - imr i · L- __ 1 7 75 -i V · - - J -- - - - _ - will be transferred using • _ I - •• • • -as · ' _ ·· --- - - _ · · · · · -·- - - ·-4 Costs f r this p ograrn fo r a pe riod o f one year• estimated to be $47 403 00 t · · V ' hich must be ded _' 1- f ou r percent 4% fee to t h e __ ·- ·· · _· making _ he_total _am nt S49 29 9 12 · _ · _· ··- __·_ - •' beg_inning l June_ 1956 a r e al -' - f - 1 - ' f -t · · · ha ·· requ fed · _ _ - ·- - · 11to submit to them a SlL'Tlmary accounting on an _· - _ ·-- · · · · - · a r tJJ annual basis o f a ll m nies r ece i ved fr om the Also t - ii i · __' it has been_ requ_es ted that an ' unexpended funds be _r eturned ---- i- it•- · as soo as possible upon t he close of the g rant year ·- -· ·__ t ·'· - - ' __ - - ·Th q-ui em n•t for a s ix months informal _ _-_·_ accounting on t he p i r t of the principal investi gator is waived i · · --· · t·· ·- - - ·-- 6- - ¼ _· --- · - - - - ' - • -- 1· · ·Title to an·y p rmanent equipm ent purchased by - --_ · - · • - fund s granted t he h a l l be retained by the · · • i _lie_u o f hig he r ove r e ad rates • •• •• • • J · • • _ • • • • • • • • • •• · · · - •- ·• -- _ - --- - - -'0-- _ _ -c- -- ·- r • -- a --•-- - - ·· · - ·- - · -l ···---·- L • c · · or lS7-175 c i e J 10 1 977 E2 WPDET CL BY 187475 · · ·· ' -- _ - · ' r-1 by out 'iorlt y of 1 3747 - dutc J uno 1977 © -- ·· c - - - -- - - - - - - -IJ rnzr 1 2 • '1 • - ' - - • I• -· -· - Ci ' CL BY 13 475 _ -3- ' - ·-- - --- - _ 1_ 8 In connection with tn vel under· thi s project it is agree_d that t he Agency_wil-l ' 3-CC_ept_ the t vel _doc_umei tc3 tion ·and accountin g w h- c nfo rm with the practices of the - · _University - ··'· · ·· - · - - · · - · · - - -i · - - __ - __ __· -__ -__ _· __ - - -e----- - ·- -- -- ·_--0- - g _ It ·ts agr eed_that Je _hry ca l r e_pQ_rts re flcct1J1g_the • -__ · - - progress· of the research-·p r ogrim shall be subm itted at mutually acceptab_le int ervals • ••• - 1-_ __ - · _ · •· · ·_ - t · - -- - - - · • • • -· -- - - --- _-J _ · · ___ - -- ·--- - -__ -· - --- ---· _ · 2 _ - · _ - • - • - - ____ _ -·· · · - - -·· -· · c ··· f -·- _ - - - _ PPROVED Division APPHOVED FOR - - OBLIGATION OF FUNDS _ _ - - - - -' · - · - • S' - ·_· · r -- - --· - _ · Attachment P r op0s2 1 Budge t ' Date L I- l flr 6_ J Distribution Origii ia l -d ly - J SS Cb- ------- Do - - c uJ 1-- t - by c ut r ity ot· 187475 2 c Jui o 1 977 E2 I DE CL EY 137 75 ' ' - p t • ' _ccec ¥e -- ' l 475- · --- ---- 7 n' t ori t'J of -_ _ • _ te Jt 1o- 1977 · · z - -- _ - •· · j - - - - t iJ 1 -- 0 • ' - - ·· • CL B'i 137475 0 l' - -• 4 l • _• _ - · - --- · -· ·• _ • _ Pi- OPOSA L -l · ·- _ -- · · _ I • ' ' 7' #' I PDE' i' r ··· I and Evaluation of Chemical Compounds Havirrg Centra l Nervous - - - -- - - ' _ __· - __ _ - Syst ·Activ·it-ies ·11 •·• - - _- _• - ------ - -- _· · ' __The program · - ··' • • _- · ·- - - c - - - i necessarily divided into s evera l _ ·- -- ·a - ' _ ---- ·- · · ' - _ ' -- ·- -_ r -· - - ·- parts s_o m _ f which are suppor ted by g r ant s other than that of -·-- · _ - - --- -- - _ · · - - - - _ __ as int egr i l p2 rts of ·- · ·- the program Other agencies who c ontr i bute a r e $ · • ' • - l • and the -_ y -·_ i· ·_ _· --· _ ·- - - · -- -0 • • - -· · -- -- ---- •• -·· · which cont ribute a maj o r ·p ortion of their capacity '- r· · -·Facilities - -- - -- · · - _ ·- - -- _ ·- - _ · ' ·•to'Yard t he program a r e a s follo ws r• - - -- · _ ----·- --· - - -- -- •· ·- - t · _- the d ir ection of -- _ _ -2 • t- u d e r the directio n _ ___ _ _ __ _ _ _ _ _ - - and - ·· · ------ -· De· -- · ····c• JCd t o ·· - by ll 't' -1· - '' - ·- •-vl cy Of 187475 c i t Jt c 1977 • ---- -- •• ·• • I •1 --- c · t o· -·• · rity of 137475 J t 1C 1 977 - • - • _ _ _ - 1 - t · - '· ET CL BY 187475 _ ··---·· -- _- · -- - - - -- • _ - -- ·at 3 _ t - i u_n • h c- - _ -•• ' - ½ttt_ L 1' i d Jf __ _sJJ j ' est ng a_6 t t s der ·- - -- -- stro'q r i t - -- --- _or_ • · ·-· a uxilliar y - ·--· t he dir ect ion ----- - -· ·-- _ -- f t T he gener i 1 pr ogram t o be conlinued by these various -- - ' - - -- facilities is the discove r y _ an _rl complete screening and testing __ _ _·· - 1• 'r - · ·-·· · of a n umb r f mat e r ials capable of µro Iuc in g alter ti rns in _ ' Do crad cd t o by a·•· or i t7 of 1 3 7475 du t c Ji 1c 1 977 _ -· - - _ I _ - Il I'vET CL BY 187475 r •·• _ a • • - 1 - - - -- · - - 3 • ·- - ·•· • • - - ·· · -· -- -- •·· 4• - •• - - - - in human beha r ior _·· ···such' fund rnental rese ar·ch· on ·mecnanisms - -i - - -· --- _ - -- --- -- - _- - - - - - ·- - -- · · - _or'actio anu structure - activity relationships as is necessary to the • _ - _ Jo _ - __ _- - -- -- •-•• • • • •• - •• -- • c·o·n · - t t - € i - %_- l · und a · as · e- _ _ •-- -• • - • - - d•• • _ - • · - _ ·-- · · quired i n addition to the p ·act ic al evaluation of them · •--- _-_ · - ·- · '_ · ·· · -· _ - -- · ·· c - - · ---· _ -- · _ _ I • - • Compounds -· · · _- · - '· · ·rr6 -- n· J - - il i b e luated in addition to those of special - - · - interest to the - -- - _ · - - ____ · '· · ' t it f- - - - - - l - - _ ' _dis sed ii°h PI_ - ct - or t h e coming yea r have· been the fepresenta tive and plans a r e --·----·· · _ -- ·- - 0 - '· _ hu mans of a par ticular r atura l p r oduct to · - · · ·- -- - b - p ·- by- the 0 - · - ' 1 -· - This - ' _ · _ evaluat ion ese nts· difficulti es of a n a ture -- - · 1' • · ·-· · · w 1ich r iakes it a unique pr ob lem _ - - · ·-- 3 T o e valuate in hum an beings a substance· 0 - - • 4 •• 4 • - - - · _ - - - o- • _ _ '- - - -- - - which we now believe has the ab ility to counteract the ineb r iating effects of ethyl alcohol -r-- '2 d t 0 •' r · i J •ity of 87475 t Jt 110 1977 ' T• -o _ - ---